Methyltetrazine-amido-N-bis(PEG4-acid)

Modify Date: 2024-01-10 10:58:17

Methyltetrazine-amido-N-bis(PEG4-acid) Structure
Methyltetrazine-amido-N-bis(PEG4-acid) structure
Common Name Methyltetrazine-amido-N-bis(PEG4-acid)
CAS Number 2639395-39-2 Molecular Weight 725.8
Density N/A Boiling Point N/A
Molecular Formula C33H51N5O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyltetrazine-amido-N-bis(PEG4-acid)


Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only[1].

 Names

Name Methyltetrazine-amido-N-bis(PEG4-acid)

 Methyltetrazine-amido-N-bis(PEG4-acid) Biological Activity

Description Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only[1].
Related Catalog
References

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.  

 Chemical & Physical Properties

Molecular Formula C33H51N5O13
Molecular Weight 725.8
Storage condition -20°C
Water Solubility DMSO, Acetonitrile