138261-41-3

• 常用中文名：吡虫啉
• 常用英文名：Imidacloprid
• CAS号：138261-41-3
• 分子式：C₉H₁₀ClN₅O₂
• 分子量：255.661
• 相关类别： 化学农药原药 杀虫剂 其他杀虫剂
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-02 19:46:04
• Imidacloprid是一种有效且广泛使用的新烟碱类农药,用于控制谷物,蔬菜,茶叶和棉花的害虫。

名称

• 中文名: 1-((6-氯吡啶-3-基)甲基)-3-硝基咪唑烷-2-亚胺
• 英文名: (E)-imidacloprid
• 中文别名: 吡虫啉
• 英文别名: 1-((6-chloropyridin-3-yl)methyl)-3-nitroimidazolidin-2-imine; MFCD01721131; EINECS 200-835-2; Imidacloprid; 1-((6-Chloro-3-pyridinyl)methyl)-N-nitro-imidazolidinimine

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 442.3±55.0 °C at 760 mmHg
• 熔点: 144ºC
• 分子式: C₉H₁₀ClN₅O₂
• 分子量: 255.661
• 闪点: 221.3±31.5 °C
• 精确质量: 255.052307
• PSA: 89.04000
• LogP: -0.43
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.706
• 储存条件: 0-6°C
• 水溶解性: 0.061 g/100mL at 20 ºC

生物活性

• 描述: Imidacloprid是一种有效且广泛使用的新烟碱类农药,用于控制谷物,蔬菜,茶叶和棉花的害虫。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
• 体外研究: 在脂肪细胞(3T3-L1),肝细胞(HepG2)和肌管(C2C12)细胞培养模型中,吡虫啉降低了胰岛素刺激的葡萄糖摄取。用吡虫啉处理减少了蛋白激酶B(AKT)的磷酸化,这是胰岛素信号传导的主要调节因子之一,而不改变总体AKT表达。吡虫啉降低了核糖体S6激酶(S6K)的磷酸化,这是AKT的下游靶标,也是胰岛素信号传导的反馈抑制剂[1]。
• 体内研究: 高剂量的吡虫啉引起认知功能的恶化,特别是在幼鼠中,并且这种恶化可能与相关基因表达的变化有关。在婴儿模型组中,在2和8mg/kg剂量下以及在成年大鼠中以8mg/kg剂量显着减少学习活动。此外,发现GRIN1,SYP和GAP-43的表达水平无显着变化[2]。早期发展暴露于吡虫啉对斑马鱼的神经行为功能具有早期和持续影响。在幼虫中,两种剂量的发育性吡虫啉暴露显着降低了游泳活动。在青少年和成年鱼类中,吡虫啉的发育暴露显着降低了新的坦克探索和增加感觉运动对惊吓刺激的反应[3]。在20mg/kg /天时观察到体重增加的减少,并且在尸检时,在该剂量水平下肝脏,肾脏和肾上腺的相对体重也显着增加。在最高剂量暴露时,自发运动活性也降低,因为血液学和尿液参数没有显着变化。大剂量吡虫啉暴露的大鼠脑,肝,肾均有轻度病理改变[4]。 20mg/kg的吡虫啉在肝脏中产生SOD,CAT,GPx,GSH,LPO的显着变化;大脑中的SOD,CAT和GPx以及肾脏中的LPO [5]。高剂量的吡虫啉特异性抑制细胞介导的免疫应答,这可从DTH反应降低和T淋巴细胞对PHA的刺激指数降低中看出。在脾脏和肝脏中也观察到显着的组织病理学改变。小鼠足垫切片的组织病理学分析显示剂量相关的DTH反应抑制[6]。
• 动物实验: 大鼠：成年女性分为四组。一组用作对照，并通过管饲法给予玉米油作为载体。向雌性大鼠给予3组5,10和20mg / kg /天的吡虫啉90天。在整个实验期间记录体重，食物消耗和临床毒性迹象。在初始和90天收集尿液用于尿液分析。每周对每组的个体动物进行称重并记录体重[4]。小鼠：吡虫啉每天以10,5或2.5mg / kg口服给药28天。体液和细胞免疫应答的具体参数，包括对绵羊红细胞的血凝抗体（HA）滴度（SRBC; T依赖性抗原），对SRBC的迟发型超敏反应（DTH）和响应于植物血凝素的T淋巴细胞增殖（PHA） ）评估[6]。
• 参考文献:

  [1]. Kim J, et al. Imidacloprid, a neonicotinoid insecticide, induces insulin resistance. J Toxicol Sci. 2013;38(5):655-60.

  [2]. Kara M, et al. Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model. Int J Exp Pathol. 2015 Oct;96(5):332-7.

  [3]. Crosby EB, et al. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. Neurotoxicol Teratol. 2015 May-Jun;49:81-90.

  [4]. Bhardwaj S, et al. A 90 days oral toxicity of imidacloprid in female rats: morphological, biochemical and histopathological evaluations. Food Chem Toxicol. 2010 May;48(5):1185-90.

  [5]. Kapoor U, et al. Effect of imidacloprid on antioxidant enzymes and lipid peroxidation in female rats to derive its No Observed Effect Level (NOEL). J Toxicol Sci. 2010 Aug;35(4):577-81.

  [6]. Badgujar PC, et al. Immunotoxic effects of imidacloprid following 28 days of oral exposure in BALB/c mice. Environ Toxicol Pharmacol. 2013 May;35(3):408-18.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Imidacloprid : Fluka REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 138261-41-3 SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC Xn HarmfulR22 For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordWarning Hazard statement(s) Harmful if swallowed. Very toxic to aquatic life with long lasting effects. Precautionary statement(s) Avoid release to the environment. Dispose of contents/ container to an approved waste disposal plant. Supplemental Hazardnone Statements Other hazards - none SECTION 3: Composition/information on ingredients Substances Formula: C9H10ClN5O2 Molecular Weight: 255,66 g/mol CAS-No.: 138261-41-3 Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration Imidacloprid CAS-No.138261-41-3Acute Tox. 4; Aquatic Acute 1; <= 100 % Aquatic Chronic 1; H302, For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas, nitrogen oxides (NOx) Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Specific end use(s) A part from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Do not let product enter drains. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: solid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity no data available LD50 Oral - rat - 410 mg/kg LC50 Inhalation - rat - > 5.323 mg/m3 LD50 Dermal - rat - > 5.000 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: NJ0560000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information Toxicity no data available Toxicity to fishLC50 - Oncorhynchus mykiss (rainbow trout) - 211 mg/l - 96 h Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects no data available SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 3077IMDG: 3077IATA: 3077 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Imidacloprid) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Imidacloprid) IATA:Environmentally hazardous substance, solid, n.o.s. (Imidacloprid) Transport hazard class(es) ADR/RID: 9IMDG: 9IATA: 9 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: yesIMDG Marine pollutant: yesIATA: yes Special precautions for user Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids. SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment Further information only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ0560000 CHEMICAL NAME : 2-Imidazolidinimine, 1-((6-chloro-3-pyridinyl)methyl)-N-nitro- CAS REGISTRY NUMBER : 138261-41-3 LAST UPDATED : 199806 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C9-H10-Cl-N5-O2 MOLECULAR WEIGHT : 255.69 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 410 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5323 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 98 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S209,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4550 mg/kg/13W-C TOXIC EFFECTS : Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 36(1,pt2),64,1997

安全

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302-H312-H319-H332
• 警示性声明: P210-P280-P305 + P351 + P338
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): N: Dangerous for the environment;Xn: Harmful;F: Flammable;
• 风险声明 (欧洲): R11
• 安全声明 (欧洲): 26-36-22
• 危险品运输编码: UN 2588
• RTECS号: NJ0560000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933399026

海关

海关编码	2933399026