193611-72-2

• 常用中文名：BRL15572 盐酸盐
• 常用英文名：BRL-15572
• CAS号：193611-72-2
• 分子式：C₂₅H₂₉Cl₃N₂O
• 分子量：479.87
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) 5-HT Receptor 拮抗剂
• 发布时间：2018-03-22 08:00:00
• 更新时间：2024-01-11 17:39:30
• BRL-15572双盐酸盐是5-HT1D受体拮抗剂，pKi为7.9，与5-HT1A和5-HT2B受体的亲和力同样较强，对5-HT1B受体抑制性较弱。

名称

• 中文名: BRL15572 盐酸盐
• 英文名: BRL 15572 hydrochloride,3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanolhydrochloride
• 中文别名: 四氢罂粟碱盐酸盐
• 英文别名: 1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-, hydrochloride (1:1); 3-[4-(3-Chlorophenyl)-1-piperazinyl]-1,1-diphenyl-2-propanol hydrochloride (1:1); TCMDC-123456; 3-[4-(3-Chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride (1:1); 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride; BRL-15572 (dihydrochloride)

物化性质

• 沸点: 580.7ºC at 760 mmHg
• 分子式: C₂₅H₂₉Cl₃N₂O
• 分子量: 479.87
• 闪点: 305ºC
• PSA: 26.71000
• LogP: 5.45990
• 外观性状: 粉末
• 蒸汽压: 2.51E-14mmHg at 25°C
• 储存条件: Desiccate at +4°C

生物活性

• 描述: BRL-15572双盐酸盐是5-HT1D受体拮抗剂,pKi为7.9,与5-HT1A和5-HT2B受体的亲和力同样较强,对5-HT1B受体抑制性较弱。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/BRL-15,572

  [2]. Fujii H, Takatori S, Zamami Y, Hashikawa-Hobara N, Miyake N, Tangsucharit P, Mio M, Kawasaki H.Adrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries.Br J Pha

  [3]. González-Hernández A, Manrique-Maldonado G, Lozano-Cuenca J, Mu?oz-Islas E, Centurión D, Maassen VanDenBrink A, Villalón CM.The 5-HT(1) receptors inhibiting the rat vasodepressor sensory CGRPergic outflow: further involvement of 5-HT(1F), but not 5-HT(1A)

  [4]. Rocha-González HI, Blaisdell-López E, Granados-Soto V, Navarrete A.Antinociceptive effect of 7-hydroxy-3,4-dihydrocadalin isolated from Heterotheca inuloides: role of peripheral 5-HT? serotonergic receptors.Eur J Pharmacol. 2010 Dec 15;649(1-3):154-60. Ep

  [5]. González-Hernández A, Mu?oz-Islas E, Lozano-Cuenca J, Ramírez-Rosas MB, Sánchez-López A, Centurión D, Ramírez-San Juan E, Villalón CM.Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats.Eur J Pharmacol. 2010