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848-21-5

848-21-5结构式
848-21-5结构式

化源商城直购

中文名 诺孕烯酮
英文名 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one
中文别名 三烯炔诺酮
英文别名 Ethynyl trienolone
Ogyline
描述 去甲孕酮,孕激素或合成孕激素,是一种孕激素受体激动剂。去甲三烯酮常用作避孕药中的孕激素化合物,可与炔雌醇联合使用[1]。
相关类别
密度 1.21g/cm3
沸点 498.1ºC at 760 mmHg
熔点 169ºC
分子式 C20H22O2
分子量 294.38700
闪点 211.2ºC
精确质量 294.16200
PSA 37.30000
LogP 3.33270
折射率 1.615

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8960080
CHEMICAL NAME :
19-Nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-
CAS REGISTRY NUMBER :
848-21-5
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H22-O2
MOLECULAR WEIGHT :
294.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
1168 ug/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
1642 ug/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,429,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
1 mg/kg
SEX/DURATION :
female 36 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,511,1979