HDAC6/HSP90-IN-1 structure
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Common Name | HDAC6/HSP90-IN-1 | ||
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CAS Number | 2411955-43-4 | Molecular Weight | 511.61 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C28H37N3O6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of HDAC6/HSP90-IN-1HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1]. |
Name | HDAC6/HSP90-IN-1 |
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Description | HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1]. |
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Related Catalog | |
Target |
HDAC6:4.32 nM (IC50) HSP90:46.8 nM (IC50) HDAC3:1312 nM (IC50) HDAC1:1878 nM (IC50) HDAC8:3720 nM (IC50) |
References |
Molecular Formula | C28H37N3O6 |
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Molecular Weight | 511.61 |