Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tos-PEG2-O-Propargyl
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Propargyl-PEG3-Tos
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Propargyl-PEG3-Tos
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1119249-30-7

1119249-30-7 structure

1119249-30-7 structure

Name: Tos-PEG2-O-Propargyl
Chemical Name: 2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate
CAS Number: 1119249-30-7
Molecular Formula: C₁₄H₁₈O₅S
Molecular Weight: 298.35500
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-03-24 04:25:23
Modify Date: 2024-01-07 22:34:22
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].

Name	2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate
Synonyms	2-(2-(prop-2-ynyloxy)ethoxy)ethyl 4-methylbenzenesulfonate 3,6-dioxanon-8-yn-1-yl p-toluenesulfonate 1-O-tosyl-3,6-dioxanon-8-yne

Description	Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Molecular Formula	C₁₄H₁₈O₅S
Molecular Weight	298.35500
Exact Mass	298.08700
PSA	70.21000
LogP	2.44750

Hazard Codes	Xi