2241914-86-1
2241914-86-1 structure
- Name: Aurora Kinases-IN-2
- Chemical Name: Aurora Kinases-IN-2
- CAS Number: 2241914-86-1
- Molecular Formula: C22H18ClN5O3
- Molecular Weight: 435.86
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
- Create Date: 2022-08-31 19:10:06
- Modify Date: 2024-01-16 09:25:10
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Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].
| Name | Aurora Kinases-IN-2 |
|---|
| Description | Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1]. |
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| Related Catalog | |
| Target |
Aurora A:90 nM (IC50) Aurora B:152 nM (IC50) |
| In Vitro | Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 0, 1, 5 and 10 μM Incubation Time: 24 hours Result: Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner. |
| References |
| Molecular Formula | C22H18ClN5O3 |
|---|---|
| Molecular Weight | 435.86 |