EGFR-IN-5

Modify Date: 2024-09-17 11:53:05

Use of EGFR-IN-5

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Name	EGFR-IN-5
Synonym	More Synonyms

Description	EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:10.4 nM (IC50) EGFRL858R:1.1 nM (IC50) EGFRL858R/T790M:34 nM (IC50) EGFRL858R/T790M/C797S:7.2 nM (IC50)
References	[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Molecular Formula	C₃₁H₃₈FN₉O
Molecular Weight	571.69

MFCD31813637

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