hA2A/hCA XII modulator 1

Modify Date: 2024-01-24 17:39:20

hA2A/hCA XII modulator 1 Structure
hA2A/hCA XII modulator 1 structure
 Common Name hA2A/hCA XII modulator 1
CAS Number 2548963-55-7 Molecular Weight 501.52
Density N/A Boiling Point N/A
Molecular Formula C24H19N7O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hA2A/hCA XII modulator 1


hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].

 Names

Name hA2A/hCA XII modulator 1

 hA2A/hCA XII modulator 1 Biological Activity

Description hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].
Related Catalog
Target

hA2AAR:6.4 nM (Ki)

hA1AR:4.819 μM (Ki)

hA3:>30 μM (Ki)

References

[1]. Costanza Ceni, et al.  Discovery of first-in-class multi-target adenosine A 2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. Eur J Med Chem. 2020 Sep 1;201:112478.

 Chemical & Physical Properties

Molecular Formula C24H19N7O4S
Molecular Weight 501.52
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