B-Raf IN 11

Modify Date: 2024-01-31 13:52:23

B-Raf IN 11 Structure
B-Raf IN 11 structure
Common Name B-Raf IN 11
CAS Number 918504-27-5 Molecular Weight 458.27700
Density N/A Boiling Point 634.2°C
Molecular Formula C17H14BrF2N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of B-Raf IN 11


B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]

 Names

Name N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Synonym More Synonyms

 B-Raf IN 11 Biological Activity

Description B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]
Related Catalog
Target

B-RafV600E:76 nM (IC50)

BRAFWT:238 nM (IC50)

References

[1]. Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim). 2016 Oct;349(10):808-815.

 Chemical & Physical Properties

Boiling Point 634.2°C
Molecular Formula C17H14BrF2N3O3S
Molecular Weight 458.27700
Exact Mass 456.99100
PSA 100.30000
LogP 5.14010

 Safety Information

Hazard Codes Xi
HS Code 2935009090

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide
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