β-Glucuronide-dPBD-PEG5-NH2 TFA

Modify Date: 2024-07-16 17:19:52

β-Glucuronide-dPBD-PEG5-NH2 TFA structure	Common Name	β-Glucuronide-dPBD-PEG5-NH2 TFA
	CAS Number	2246364-63-4	Molecular Weight	1810.69
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₀H₁₀₂F₃N₇O₃₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of β-Glucuronide-dPBD-PEG5-NH2 TFA

β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

Name	β-Glucuronide-dPBD-PEG5-NH2 TFA

Description	β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog	Research Areas >> Cancer
Target	Drug-linker conjugates for ADC, Apoptosis[1]
References	[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

Molecular Formula	C₈₀H₁₀₂F₃N₇O₃₇
Molecular Weight	1810.69

β-Glucuronide-dPBD-PEG5-NH2 TFA

Use of β-Glucuronide-dPBD-PEG5-NH2 TFA

Names

β-Glucuronide-dPBD-PEG5-NH2 TFA Biological Activity

Chemical & Physical Properties