Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Calmodulin-dependentProteinKinaseIIfragment290-309
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Purity: 97.0%
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GL Biochem (Shanghai) Ltd.
China
Product Name: Calmodulin-Dependent Protein Kinase II (290-309);LKKFNARRKLKGAILTTMLA
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Purity: 98.0%
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Taiwan Oyi peptide Co. Ltd
China
Product Name: Calmodulin-Dependent Protein Kinase II (290-309)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

115044-69-4

115044-69-4 structure

115044-69-4 structure

Name: Calmodulin-Dependent Protein Kinase II (290-309)
Chemical Name: Calmodulin-Dependent Protein Kinase II (290-309)
CAS Number: 115044-69-4
Molecular Formula: C₁₀₃H₁₈₅N₃₁O₂₄S
Molecular Weight: 2273.83000
Catalog: Peptides
Create Date: 2016-07-06 12:21:16
Modify Date: 2024-01-11 19:02:52
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

Name	Calmodulin-Dependent Protein Kinase II (290-309)
Synonyms	CAM KINASE II (290-309) CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309) CaM kinase II (290-309) CALMODULIN-DEPENDENT PROTEIN KINASE II FRAGMENT 290-309 LKKFNARRKLKGAILTTMLA CALMODULIN DEPENDENT PROTEIN KINASE II CALMODULIN BINDING DOMAIN LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309) CALMODULIN-DEPENDENT PROTEIN KINASE IIFR AGMENT 290 H-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA-OH

Description	Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Neurological Disease Peptides
Target	IC50: 52 nM (calmodulin-dependent protein kinase II)[1]
In Vitro	Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity[1].
Kinase Assay	Ca2+/CaM-dependent phosphodiesterase is assayed at 30°C. The reaction mixture contains 40 mM Tris-HCl, pH 8.0, 5 mM magnesium acetate, 1 mM calcium chloride, 30 μM cGMP, 0.15 pCi of [3H]cGMP, 1 mM dithiothreitol, 20% glycerol, 0.64 mg/mL bovine serum albumin, 2.38 nM CaM, 50 pM CaM-deficient phosphodiesterase, and various concentrations of Calmodulin-Dependent Protein Kinase II (290-309). Following preincubation of the reaction mixture at 30°C, the reaction is initiated by the addition of substrate. After 50 min the reaction is terminated by boiling. Conditions are selected in which the reactions are linear with respect to time[1].
References	[1]. Payne ME, et al. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem. 1988 May 25;263(15):7190-5.

Molecular Formula	C₁₀₃H₁₈₅N₃₁O₂₄S
Molecular Weight	2273.83000
Exact Mass	2272.39000
PSA	952.95000
LogP	7.21720
Storage condition	2-8℃

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3