NH2-PEG1-CH2CH2-Boc

Modify Date: 2024-01-10 15:53:28

NH2-PEG1-CH2CH2-Boc Structure
NH2-PEG1-CH2CH2-Boc structure
Common Name NH2-PEG1-CH2CH2-Boc
CAS Number 1260092-46-3 Molecular Weight 189.252
Density 1.0±0.1 g/cm3 Boiling Point 264.9±15.0 °C at 760 mmHg
Molecular Formula C9H19NO3 Melting Point N/A
MSDS N/A Flash Point 90.5±16.7 °C

 Use of NH2-PEG1-CH2CH2-Boc


NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 3-(2-aminoethoxy)propanoate
Synonym More Synonyms

 NH2-PEG1-CH2CH2-Boc Biological Activity

Description NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 264.9±15.0 °C at 760 mmHg
Molecular Formula C9H19NO3
Molecular Weight 189.252
Flash Point 90.5±16.7 °C
Exact Mass 189.136490
LogP 0.84
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.445

 Safety Information

Hazard Codes Xn

 Synonyms

MFCD20727480
Propanoic acid, 3-(2-aminoethoxy)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 3-(2-aminoethoxy)propanoate
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