Amino-PEG3-C2-Azido

Modify Date: 2024-01-02 17:27:48

Amino-PEG3-C2-Azido structure	Common Name	Amino-PEG3-C2-Azido
	CAS Number	134179-38-7	Molecular Weight	218.25400
	Density	1.1	Boiling Point	198-202ºC
	Molecular Formula	C₈H₁₈N₄O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05	Signal Word	Danger

Use of Amino-PEG3-C2-Azido

Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].

Name	11-Azido-3,6,9-trioxaundecan-1-amine
Synonym	More Synonyms

Description	Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1].
References	[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Density	1.1
Boiling Point	198-202ºC
Molecular Formula	C₈H₁₈N₄O₃
Molecular Weight	218.25400
Exact Mass	218.13800
PSA	103.46000
LogP	0.45826
Index of Refraction	1.47
Storage condition	Amber Vial, Refrigerator, Under Inert Atmosphere

Amino-PEG3-C2-Azido MSDS(Chinese)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C,Xi
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2735
WGK Germany	3
Packaging Group	III
HS Code	2929909090

Precursor 7
CAS#:101187-39-7 Azido-PEG3-azide CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:55400-73-2 Ms-PEG4-Ms CAS#:86770-67-4 Azido-PEG4-alcohol
CAS#:134179-43-4 methanesulfonic... CAS#:134179-42-3 1-azido-11-[(te... CAS#:65883-12-7 PEG4-Ms
DownStream 3
CAS#:239081-53-9 2-[2-[2-[2-[2-(... CAS#:875770-34-6 Biotin-PEG3-azide CAS#:65883-12-7 PEG4-Ms

HS Code	2929909090
Summary	2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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