Azido-PEG3-azide

Modify Date: 2024-01-02 11:59:58

Azido-PEG3-azide structure	Common Name	Azido-PEG3-azide
	CAS Number	101187-39-7	Molecular Weight	244.25100
	Density	1.1703g/mL	Boiling Point	163-196°C
	Molecular Formula	C₈H₁₆N₆O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Azido-PEG3-azide

Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,11-Diazido-3,6,9-trioxaundecane
Synonym	More Synonyms

Description	Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.1703g/mL
Boiling Point	163-196°C
Molecular Formula	C₈H₁₆N₆O₃
Molecular Weight	244.25100
Exact Mass	244.12800
PSA	127.19000
LogP	0.56232
Storage condition	-20°C

Azido-PEG3-azide MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

2,2'-((Oxybis(e...

CAS#:112-60-7

~88%

Azido-PEG3-azide

CAS#:101187-39-7

Literature: WO2006/73314 A1, ; Page/Page column 31 ;

PROTAC Linker 16

CAS#:37860-51-8

~92%

Azido-PEG3-azide

CAS#:101187-39-7

Literature: Chemical Communications, , vol. 48, # 45 p. 5650 - 5652

Ethane,1,1'-oxy...

CAS#:638-56-2

~99%

Azido-PEG3-azide

CAS#:101187-39-7

Literature: WO2008/11157 A2, ; Page/Page column 174 ;

Ms-PEG4-Ms

CAS#:55400-73-2

~99%

Azido-PEG3-azide

CAS#:101187-39-7

Literature: Tetrahedron, , vol. 65, # 36 p. 7385 - 7392

2,2'-((Oxybis(e...

CAS#:112-60-7

~15%

Azido-PEG3-azide

CAS#:101187-39-7

Azido-PEG4-alcohol

CAS#:86770-67-4

Literature: Angewandte Chemie - International Edition, , vol. 51, # 9 p. 2151 - 2154

Bromo-PEG3-bromide

CAS#:31255-26-2

~99%

Azido-PEG3-azide

CAS#:101187-39-7

Literature: Journal of the American Chemical Society, , vol. 127, # 36 p. 12434 - 12435

Precursor 5
CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:37860-51-8 PROTAC Linker 16 CAS#:638-56-2 Ethane,1,1'-oxy... CAS#:31255-26-2 Bromo-PEG3-bromide
CAS#:55400-73-2 Ms-PEG4-Ms
DownStream 4
CAS#:929-75-9 Amino-PEG3-C2-Amine CAS#:134179-38-7 Amino-PEG3-C2-Azido CAS#:101187-40-0 PROTAC Linker 15 CAS#:65883-12-7 PEG4-Ms

Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[(18)F]fluoroethylazide, and in vivo evaluation.

Eur. J. Med. Chem. 89 , 279-95, (2014)

Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. We have designed two clo...

1-azido-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethane