PEG4-Ms

Modify Date: 2024-01-10 15:21:43

PEG4-Ms structure	Common Name	PEG4-Ms
	CAS Number	65883-12-7	Molecular Weight	272.31600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₂₀O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PEG4-Ms

PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
Synonym	More Synonyms

Description	PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₉H₂₀O₇S
Molecular Weight	272.31600
Exact Mass	272.09300
PSA	99.67000
LogP	0.08550

2,2'-((Oxybis(e...

CAS#:112-60-7

Methanesulfonyl...

CAS#:124-63-0

~79%

PEG4-Ms

CAS#:65883-12-7

Literature: Zemlyakov; Kur'yanov; Sidorova; Chupakina; Chirva Chemistry of Natural Compounds, 1997 , vol. 33, # 5 p. 563 - 567

2,2'-((Oxybis(e...

CAS#:112-60-7

Methanesulfonyl...

CAS#:124-63-0

~61%

Ms-PEG4-Ms

CAS#:55400-73-2

PEG4-Ms

CAS#:65883-12-7

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

N/A

CAS#:1321923-30-1

PEG4-Ms

CAS#:65883-12-7

Literature: Jalisatgi, Satish S.; Kulkarni, Vikas S.; Tang, Betty; Houston, Zachary H.; Lee, Mark W.; Hawthorne, M. Frederick Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12382 - 12385

2,2'-((Oxybis(e...

CAS#:112-60-7

PEG4-Ms

CAS#:65883-12-7

Ms-PEG4-Ms

CAS#:55400-73-2

PEG4-Ms

CAS#:65883-12-7

Azido-PEG3-azide

CAS#:101187-39-7

PEG4-Ms

CAS#:65883-12-7

Amino-PEG3-C2-Azido

CAS#:134179-38-7

PEG4-Ms

CAS#:65883-12-7

nh2-tteg-nh-dns

CAS#:914311-67-4

Methanesulfonyl...

CAS#:124-63-0

Ms-PEG4-Ms

CAS#:55400-73-2

PEG4-Ms

CAS#:65883-12-7

Precursor 5
CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:124-63-0 Methanesulfonyl... CAS#:55400-73-2 Ms-PEG4-Ms CAS#:101187-39-7 Azido-PEG3-azide
CAS#:134179-38-7 Amino-PEG3-C2-Azido
DownStream 8
CAS#:352439-36-2 Azide-PEG8-alcohol CAS#:86770-74-3 Amino-PEG4-alcohol CAS#:86770-67-4 Azido-PEG4-alcohol CAS#:106984-09-2 N-Boc-PEG4-alcohol
CAS#:134179-38-7 Amino-PEG3-C2-Azido CAS#:352439-37-3 NH2-PEG8-OH CAS#:172531-37-2 2-[2-[2-(2-azid... CAS#:134978-99-7 Amino-PEG3-CH2COOH