Mal-​C2-cyclohexylcarboxyl-hydrazide TFA

Modify Date: 2024-01-08 16:24:33

Mal-​C2-cyclohexylcarboxyl-hydrazide TFA Structure
Mal-​C2-cyclohexylcarboxyl-hydrazide TFA structure
Common Name Mal-​C2-cyclohexylcarboxyl-hydrazide TFA
CAS Number 359436-59-2 Molecular Weight 365.305
Density N/A Boiling Point N/A
Molecular Formula C14H18F3N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-​C2-cyclohexylcarboxyl-hydrazide TFA


Mal-​C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarbohydrazide trifluoroacetate (1:1)
Synonym More Synonyms

 Mal-​C2-cyclohexylcarboxyl-hydrazide TFA Biological Activity

Description Mal-​C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C14H18F3N3O5
Molecular Weight 365.305
Exact Mass 365.119843

 Synonyms

MFCD01863409
4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarbohydrazide trifluoroacetate (1:1)
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