m-PEG4-Tos

Modify Date: 2024-01-10 13:34:28

m-PEG4-Tos structure	Common Name	m-PEG4-Tos
	CAS Number	62921-76-0	Molecular Weight	380.45400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₆O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of m-PEG4-Tos

m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

Name	2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol,4-methylbenzenesulfonic acid
Synonym	More Synonyms

Description	m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

Molecular Formula	C₁₆H₂₆O₇S
Molecular Weight	380.45400
Exact Mass	380.15000
PSA	119.90000
LogP	1.99740

Tetraethylene g...

CAS#:23783-42-8

Tosyl chloride

CAS#:98-59-9

~99%

m-PEG4-Tos

CAS#:62921-76-0

Literature: Vallee, M. Robert J.; Majkut, Paul; Wilkening, Ina; Weise, Christoph; Mueller, Gregor; Hackenberger, Christian P. R. Organic Letters, 2011 , vol. 13, # 20 p. 5440 - 5443