Methylpyridine

Methylpyridine is a homologue of pyridine. Pyridine is an aromatic hydrocarbon and is also a six-membered ring. It is similar in some respects to benzene, but different from benzene. For example, toluene has no isomer, while methylpyridine has three isomers. Namely 2-methylpyridine [1], 3-methylpyridine [2] and 4-methylpyridine [3]. The relative molecular mass is 93.13. Naturally present in coal tar, it is chemically active, and can undergo side chain oxidation and substitution on nitrogen, or condensation with aldehydes and ketones under base catalysis. [1] Also known as α-methylpyridine, α-picoline. Colorless liquid. There is a strong irritating odor. The relative density is 0.9462. Melting point - 66.8 ° C. The boiling point of 128.8 ° C. The refractive index is 1.4957. A flash point of 26 ° C. Soluble in water and acetone, miscible with ethanol and ether. It is composed of azeotrope with water. The content of this product is 52% and the azeotrope is 93.5 °C. Rat oral LD501410 mg / kg. Uses: raw materials for the production of 2-vinyl pyridine; pesticide raw materials, production of "oxazapine", "pyridine-2,5-dicarboxylate", "flying", "chloridine", "diode" "Olinic acid", "methyl iodide-2-pyridine aldehyde oxime", "muscarinic" and the like. [2] Also known as β-picoline, β-picoline. Colorless transparent liquid. Irritating smell. Slightly sweet. The relative density is 0.9560 and 0.9613 (15 ° C). Melting point -18.3 ° C. The boiling point is 143.9 ° C. The refractive index is 1.5403. Flash point 36 ° C (closed). Miscible with water, ethanol and ether. This product is azeotrope with water. The content of this product is 27% and the total boiling point is 96.7 °C. This product is different from [1] and [3] in that its methyl reactivity is poor. It has a stimulating effect on the skin and can also be absorbed through the skin. Its vapor irritates the eyes and respiratory tract, causing inflammation. In severe cases, it causes blistering, vomiting, headache and other symptoms. Rat oral LD50790mg/kg. Uses: pesticide raw materials, production of herbicides, insecticides, fungicides, such as "original nicotine", "pyridinol" and rodenticide "anti-rat spirit"; food additives, meat products processing when adding 2-A Pyridine, combined with myoglobin, prevents oxidation and keeps the color of the meat fresh; adds [2] to foods such as bread, cakes, rice products, dairy products, ham and sausages, which can strengthen the role of vitamins. It can be used in place of vitamin B; it can be added to infant formula, milk powder for women during pregnancy, food and beverages; it can also be used as medicine for the treatment of niacin deficiency; feed additives; Amide or substitute nicotinamide; alcohol modifier; dye intermediate; rubber vulcanizing agent and raw material of film sensitizer. [3] Also known as γ-methylpyridine, γ-picoline. Colorless liquid. It is flammable. There is an unpleasant smell. It has a sweet taste. If impurities are mixed in, the color gradually turns yellow. The relative density is 0.9558. The temperature of 3.7 ° C. The boiling point is 144.9 ° C. The refractive index is 1.5064 (17 ° C). The flash point is 56 °C. Soluble in water, ethanol and ether. This product forms an azeotrope with water. The content of this product is 63.5% and the total boiling point is 97.4 °C. It is irritating to the skin, eyes and mucous membranes. It can be felt even if the concentration is 1×10-6 due to bad odor. It can be prevented early. After poisoning, nausea, vomiting, headache, severe visceral and nerve center diseases. Rat oral LD501290mg/kg. Uses: pharmaceutical raw materials, production of treatment of tuberculosis drugs "isoniazid", antidepressant "smoke amide", antidote "double complex phosphorus"; pesticide raw materials, production of pesticides and herbicides; can also be used for dyes, rubber aid Agent, fabric waterproofing agent, resin curing agent; raw materials such as nicotin, 2-amino-4-methylpyridine (veterinary drug), pyridine-4-carboxylic acid (anti-coagulant).