Titanic anti-tumor drugs are a new class of bio-targeted therapeutic tumor drugs. The current anti-tumor drugs commonly used in the Chinese market include: gefitinib, imatinib, imatinib mesylate, Nilotinib, sunitinib, lapatinib. Gefitinib is a highly specific anti-tumor targeted therapy developed by AstraZeneca, UK. It is the first molecularly targeted drug for the treatment of non-small cell lung cancer, by selectively inhibiting it. The epidermal growth factor receptor tyrosine kinase (EGFR-TK) signaling pathway plays a role. Imatinib is a novel 2-aniline pyrimidine tyrosine kinase inhibitor. It can effectively inhibit the activity of Bcr-abl tyrosine kinase at the cellular level, which is the product of abnormal expression of Ph chromosome in chronic myeloid leukemia (CML), so imatinib can selectively inhibit Ber-abl positive cell lines. Cell and chronic myelogenous leukemia cells proliferate and induce apoptosis. Sunitinib is a multi-target tyrosine kinase inhibitor, including platelet-derived growth factor receptor, vascular endothelial growth factor receptor and various forms of mutations that activate stem cell factor receptors, inhibit tumor cell RTKs expression dysregulation and anti-tumor Angiogenesis. Metabolically dependent cytochrome P450 enzymes. It is suitable for the treatment of gastrointestinal stromal tumors resistant to imatinib or post-treatment, or for the treatment of renal cell carcinoma.
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Amino compound
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Oxy-containing amino compound
Cycloalkylamines, aromatic monoamines, aromatic polyamines and derivatives and salts thereof
Acyclic monoamines, polyamines and their derivatives and salts
Amide compound
Sulfonic acid amino compound
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Alcohols, phenols, phenolic compounds and derivatives
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2-cycloalcohol
Halogenated, sulfonated, nitrated or nitrosated derivatives of alcohols
Extremely halogenated, sulfonated, nitrated or nitrosated derivatives of phenols
Phenol and its halogenated, sulfonated, nitrated or nitrosated derivatives
Acyclic alcohol
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Nitrogen-containing compound
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Nitrile compound
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Organic derivative of hydrazine or hydrazine
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Terpenoid
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Ether compounds and their derivatives
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Ether, ether alcohol
Halogenation, sulfonation, nitration or nitrosation of ethers, ether alcohols, ether phenols
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Aldehyde
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Carboxylic compounds and derivatives
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Cyclic carboxylic acid
Halogenation, sulfonation, nitration or nitrosation of carboxylic acids
Halogenation, sulfonation, nitration or nitration of carboxylic anhydrides
Carboxylic acid halide
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Salt of carboxylic acid ester and its derivatives
Acyclic carboxylic acid
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Hydrocarbon compounds and their derivatives
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Aromatic hydrocarbon
Cyclic hydrocarbon
Hydrocarbon sulfonate
Hydrocarbon halide
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Acyclic hydrocarbon
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Ketone compound
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Alkyl ureas and their derivatives and salts
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Inorganic acid ester
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Heterocyclic compound
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Diazo, azo or azo compound
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Organosilicon compound
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Organometallic compound
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Organic palladium
Organic germanium, cobalt, strontium, barium, gallium, germanium, germanium, germanium, germanium, etc.
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Organic sulfur compound
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Organometallic salt
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Organic fluorine compound
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Fluorobenzoic acid series
Fluorobenzonitrile series
Fluorobenzaldehyde series
Fluorobenzyl alcohol series
Fluoroanisole series
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